https://www.kirschnerlab.org/home_test daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904282300-MD9GMY1N6FTBHZT7D95V/Screen+Shot+2021-05-12+at+1.01.46+PM.png home_test https://www.kirschnerlab.org/home daily 1.0 2023-05-22 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683912596288-C0UF79HKCL33WSMBQMFK/image-asset.jpeg Home - Kirschner Lab In the Kirschner lab, we are broadly interested in fundamental questions in cell and developmental biology, especially around biological organization in space and time, that we feel still do not have satisfactory answers. The big themes we work on are listed below: https://www.kirschnerlab.org/new-gallery-1 daily 0.75 2023-05-12 https://www.kirschnerlab.org/test_cover daily 0.75 2023-05-12 https://www.kirschnerlab.org/new-cover-page daily 0.75 2023-05-12 https://www.kirschnerlab.org/members daily 0.75 2024-06-13 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/7e73f512-562c-4f38-a947-0269f607fb43/Screenshot+2023-05-25+075622.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/cf7bacfd-e42b-4d11-82b5-6cf20701627d/matt_sonnett_kirsch_website_pic.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/02df89ca-ba33-479a-a14c-cb32b5aa89ae/Xili+Liu.jpeg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/d0df3924-5063-4c60-99f9-39012ee8d294/Lipofskyphotodotcom+-963690.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/a29f7a98-0d05-4e0a-b8fd-995f234a7ed0/Lipofskyphotodotcom+-963993.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/283bd75d-2159-4afd-b659-c069f40480b3/Mike+Gage.png Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/318601d6-a258-4b07-8387-a2e54d2dd2e8/Image%281%29.jpeg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/622e374f-1503-4ed6-a635-b28c2258356f/Lipofskyphotodotcom+-964060.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/4c3362c3-8af2-4c1d-b852-79e437d76088/Image+%284%29.jpeg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/7e1f62ef-3548-4b42-a64a-3300791d0037/Bai%27s+photo.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/245ef94c-8486-41a5-b00e-440c7363edac/HMS+2024.jpg Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kirschnerlab.org/home-page-20-1 daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904222381-W0PCVYBVF3CBMF17IFA7/Marks_Lab_frontpage_graphic.png Home Page 2.0 (Copy) - Debora Marks Lab ML to accellerate biology What will we do when there are a billion genomes? https://www.kirschnerlab.org/home-page-20 daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904226047-WUSLN5ANX4L89QDUTOKO/Marks_Lab_frontpage_graphic.png Home Page 2.0 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904226025-X7PDZRFYP4NYLGCBVS1W/MarksLabHomepage_proto3_gradient.png Home Page 2.0 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904226034-GFNY62X7LLDDNRLJ7M4W/couplings.png Home Page 2.0 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904226040-GFRVN1GM4I0GMNVFIHNZ/image-asset.jpeg Home Page 2.0 https://www.kirschnerlab.org/members-1 daily 0.75 2023-05-12 https://www.kirschnerlab.org/home-page-20-slider daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904229233-VX2RPTEZBDBS1KICAV1A/MarksLabHomepage_proto3_gradient.png Home Page 2.0 (slider) - WHAT WILL WE DO WHEN THERE ARE A BILLION GENOMES? We develop computational approaches to make sense of genetic variation. And we learn to design biological tools for environmental and human health. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904229249-R93OSFHPDKPKTTCDGL0J/F1.large.jpg Home Page 2.0 (slider) - Generative probabilistic biological sequence models that account for mutational variability Here we introduce a structured emission distribution (the MuE distribution) that accounts for mutational variability (substitutions and indels) and use it to construct generative and predictive hierarchical Bayesian models (H-MuE models). https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904229226-HTFL9EI21CB896WWENEA/couplings.jpg Home Page 2.0 (slider) - EVOLUTIONARY COUPLINGS PREDICTING PROTEIN STRUCTURES, COMPLEXES, AND CONFORMATIONAL PLASTICITY FROM EVOLUTION https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904229241-AH8DSLLFB41XYHE3PZI9/Screenshot+2021-02-10+163944.png Home Page 2.0 (slider) - Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact Here, we used multiplexed, sequencing-based assays to measure the effects of 2,695 VKOR missense variants on abundance and 697 variants on activity in cultured human cells. https://www.kirschnerlab.org/members-image-link-fix daily 0.75 2023-05-12 https://www.kirschnerlab.org/landing-page-1 daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904234686-VR0YYZNJMV6W4YEW5HFS/MarksLabHomepage_proto3_gradient.png Debbie Marks Lab (Copy) https://www.kirschnerlab.org/contact daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683914305951-DYZH5WTW1S1KQ4DSH98K/image-asset.jpeg Contact - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kirschnerlab.org/lab-culture daily 0.75 2023-05-25 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/56d2d077-d0d3-4d0c-a351-19dd0d1eb6ad/Kirschner+lab.jpeg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/55f2a5ff-757f-40d8-9b2b-f2c44e315043/subgroup1_1.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/cba302b0-503e-40ce-96e6-d3431f207b60/microscope+room.jpeg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/25a3c46e-460d-4f69-bca4-511ca6397eff/microscope_work.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/60ada849-c3ca-4d5e-b881-782b77cc4a97/subgroup2_1.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/70ab82dd-bc2d-40d4-92f3-a3c5337a1afc/lab_work_1.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/57e302bb-adca-4164-ae28-434957f9ed84/thumbnail_IMG_1212.jpg Lab Culture - Make it stand out Kirschner Lab Hosted “World Cup Themed” Happy Hour Spring 2023 https://www.kirschnerlab.org/landing-page-2 daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904284174-NS9G0FCUPS8JNDM3SNAL/frontpage_graphic_4.png Debbie Marks Lab (Copy) https://www.kirschnerlab.org/publications daily 0.75 2023-09-20 https://www.kirschnerlab.org/home-page-30 daily 0.75 2023-05-12 https://www.kirschnerlab.org/about-us-1 daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292564-XCTLYURZ4YAP0K0QR0C8/disorderPaper_cropped.png About Us (Copy) - Structured States of Disordered Proteins from Genomic Sequences (Copy) (Copy) https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292589-IW7M3ZXX0U795S5Q1CMH/Deep_generative_models.png About Us (Copy) - Deep generative models of genetic variation capture the effects of mutations (Copy) (Copy) https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292570-OR90S7LXRQSDU75IC1SM/3D_RNA_and_functional_interactions_from_evolutionary_couplings.jpg About Us (Copy) - 3D RNA and Functional Interactions from Evolutionary Couplings (Copy) (Copy) https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292557-0C99XZDQBIDI9CWIUEC2/Model_constraints_on_sequences.jpg About Us (Copy) - Mutation effects predicted from sequence co-variation (Copy) (Copy) https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292599-U34HQPUMY277X0UWE2LE/Inferring_protein_3D_structure_from_deep_mutation_scans.png About Us (Copy) - Inferring protein 3D structure from deep mutation scans (Copy) (Copy) https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683904292583-MXSXDB646Z16UAHOL4IO/Population-specific_design_of_de-immunized_protein_biotherapeutics.PNG About Us (Copy) - Population-specific design of De-immunized Protein Biotherapeutics (Copy) (Copy) https://www.kirschnerlab.org/marc-kirschner daily 0.75 2023-05-12 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/4c5d7272-5e44-4081-a3bc-0b225b2d2a0d/Lipofskyphotodotcom+-963452.jpg Marc Kirschner - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kirschnerlab.org/cell-size daily 0.75 2023-05-12 https://www.kirschnerlab.org/importance-of-weak-protein-protein-interactions daily 0.75 2023-05-12 https://www.kirschnerlab.org/pathways-of-ubiquitin-mediated-degradation daily 0.75 2023-05-12 https://www.kirschnerlab.org/single-cell-transcriptomics-proteomics-and-developmental-strategies daily 0.75 2023-05-12 https://www.kirschnerlab.org/alumni daily 0.75 2024-07-20 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915342108-FOFG94AEF6RG3K9BGR2D/IMG-1901.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915342095-87G327SKQM90QCDAP0BW/IMG-1916.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915343778-C8WDOJ8WHVKHMOGFLZB3/IMG-1899.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915343852-VH9356SFBYKLQONHQB5V/IMG-1898.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915346043-3OSUGII214O1V9OREO6Q/IMG-1913.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915345889-7J7P4O98GG5GHGI9NO9S/IMG-1905.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915347292-20TJD5WG4XOKFOFCCQLF/IMG-1894.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915347393-N4ZFT74TFS6F6YHX80ST/IMG-1920.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915348512-07JWONUA2IME2E86A7GF/IMG-1922.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915348673-N1AZFAAD4ELLJ90YDAMV/IMG-1944.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915349924-2X8GQ3H2YACOB7TU7YEQ/IMG-1941.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915349951-FNCM1AGYKMVBOT22G0S9/IMG-1923.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915351560-K76H4R2CNDHJ2J9QF3YG/IMG-1919.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915351872-FLPDEA2RMS4056F4ZQA5/IMG-1912.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915352689-IDZORG4RUX7GG3V9A5O3/IMG-1910.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915353288-QEOB5MB8JFT79NM4K4N1/IMG-1906.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683915353898-YG5ZZ3BFMUW6ZQUZIP51/IMG-1896.JPG Alumni https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683917645936-BVZ2ONZ9RHDXAC52JQRM/kirschner-lab-past-present1.jpg Alumni https://www.kirschnerlab.org/marcathon-2024 daily 0.75 2024-07-07 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1448823f-b12d-4ef7-83f8-75edeed01b9f/Marcathon+schedule_Page_2.png Marcathon 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/ce513365-bdff-4777-802f-236433125cfa/Marcathon+schedule_Page_1.png Marcathon 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/1683917645936-BVZ2ONZ9RHDXAC52JQRM/kirschner-lab-past-present1.jpg Marcathon 2024 - Make it stand out Previous Marc Fest in 2015 https://images.squarespace-cdn.com/content/v1/645e56da651534627529c209/a43dc28b-07ff-43a1-a186-1b971f06aa7d/Marcathon+schedule_Page_3.png Marcathon 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference.